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Dendritic cell analysis focuses on studying gene expression, activation, and signaling pathways in dendritic cells (DCs), which are key antigen-presenting cells of the immune system.
These cells play a central role in bridging innate and adaptive immunity by capturing, processing, and presenting antigens to T cells. They are primarily located in peripheral tissues such as the skin and mucosal surfaces, where they detect pathogens and initiate immune responses. Upon activation, dendritic cells migrate to lymph nodes and activate naïve T cells.
Because of their essential role in immune regulation, dendritic cell profiling is widely used in immunology, inflammation research, infectious diseases, and cancer immunotherapy.
Dendritic cell analysis is commonly performed using gene expression profiling. qPCR-based approaches enable accurate and reproducible characterization of activation states and signaling pathways.
Dendritic cell biomarker list
Explore the curated list of genes involved in dendritic cell function, antigen presentation, and immune signaling.
This gene panel can be used to design customized qPCR arrays with AnyGenes®.
Example biomarkers:
CD80, CD86, HLA-DQA1, HLA-DQB1, IL12B, CCR5, CXCR4, NFKB1
Dendritic cell analysis is particularly relevant when studying immune activation, antigen presentation, and inflammatory responses.
It is commonly used to:
Dendritic cells include several subsets with specialized functions.
Conventional dendritic cells (cDCs)
Key mediators of antigen presentation and T-cell activation.
Plasmacytoid dendritic cells (pDCs)
Specialized in antiviral responses through type I interferon production.
Langerhans cells
Located in the skin and mucosal tissues, involved in immune surveillance.
Monocyte-derived dendritic cells
Generated during inflammation and involved in immune activation.
Antigen presentation and MHC molecules
HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-DMA, HLA-DOA, HLA-A, CD74, TAP2, TAPBP, PDIA3
Surface markers and activation
CD1A, CD1B, CD1C, CD1D, CD209, CD80, CD86, CD40, CD44, CLEC4C, FCER1A, FCER2, FCAR, FCGR1A
Cytokines and immune mediators
IFNG, IL12A, IL12B, TNF, TGFB1, CSF2, MIF, INHBA, IL2
Chemokines and receptors
CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL16, CCL19, CCR1, CCR2, CCR3, CCR5, CXCR1, CXCR4, CXCL1, CXCL2, CXCL8, CXCL10, CXCL12
Signaling and transcription factors
NFKB1, NFKB2, RELA, RELB, LYN, CEBPA, IFIT3, IFNGR1, TLR1, TLR2
Adhesion and regulatory genes
ICAM1, ICAM2, ITGAM, ITGB2, RAC1, CDC42, LRP1, THBS1, FAS, CDKN1A, STK4, TRAP1, ERBB2
Dendritic cell function is regulated by signaling pathways involved in pathogen recognition and immune activation.
Key pathways include:
These pathways control maturation, cytokine production, migration, and T-cell activation.
They can be analyzed through gene expression profiling using targeted qPCR panels
Analyzing dendritic cell activation can be challenging due to the diversity of cell subsets and signaling pathways involved.
Dendritic cell analysis typically relies on expression-based and pathway-focused approaches.
Workflow:
Expression-based analysis provides insights into dendritic cell activation and immune function.
It enables:
Example biomarkers:
CD80, CD86, HLA-DQA1, HLA-DQB1, IL12B, CCR5, CXCR4, NFKB1
Cancer immunology
Dendritic cells play a central role in anti-tumor immunity and immunotherapy.
Autoimmune diseases
Altered dendritic cell activity contributes to chronic inflammation and immune disorders.
Infectious diseases
They regulate immune responses to pathogens such as viruses and bacteria.
Vaccine research
Dendritic cell activation is a key parameter in vaccine development.
Understanding dendritic cell biology requires reliable and targeted gene expression tools.
Targeted qPCR panels allow focused investigation of signaling pathways, activation markers, and antigen presentation genes.
AnyGenes® supports researchers with customized qPCR panels designed for dendritic cell analysis and immune profiling.
Key advantages:
These solutions are widely used in immunology and translational research to support reproducible and high-quality pathway analysis.
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
Dendritic cells are antigen-presenting cells that initiate and regulate immune responses by activating T cells and linking innate and adaptive immunity.
Dendritic cell analysis is typically performed using gene expression profiling and qPCR-based approaches to evaluate activation and signaling pathways.
qPCR arrays, transcriptomic approaches, and targeted gene panels are commonly used.
They help characterize immune activation, antigen presentation, inflammation, and therapeutic responses.
Key genes include HLA molecules, CD markers, cytokines, and chemokine receptors such as CCR5 and CXCR4.
They can be analyzed using gene expression profiling techniques such as qPCR arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Dendritic Cells | DC1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Dendritic Cells | DC1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Dendritic Cells | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Dendritic Cells | ******* |
Biomarker list in progress. |
Looking for more answers? Visit our Help & FAQ section to find detailed information about our products, services, and technical support.
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2. Collin M, et Bigley V. Human dendritic cell subsets: an update. Immunology. (2018);154(1):3-20.
3. Kamata M, et Tada Y. Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis. Front Immunol. (2022);13:941071..
4. El-Awady AR, et al. Dendritic cells a Critical Link to Alveolar Bone loss and Systemic Disease Risk in Periodontitis: Immunotherapeutic Implications. Periodontol 2000. (2022);89(1):41-50.
5. Liu J, Zhang X, Cao X. Dendritic cells in systemic lupus erythematosus: From pathogenesis to therapeutic applications. J Autoimmun. (2022);132:102856.
6. Marciscano AE, Anandasabapathy N. The Role of Dendritic Cells in Cancer and Anti-Tumor Immunity. Semin Immunol. (2021 );52:101481.