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Cytokines and cytokine signaling pathways are central regulators of immune communication, inflammation, hematopoiesis, and tissue repair. Cytokines are small, secreted signaling proteins that act as molecular messengers between immune cells and surrounding tissues, orchestrating complex cellular communication networks.
Cytokines bind to specific receptors on target cells and activate intracellular signaling cascades that control gene expression, cell proliferation, differentiation, survival, and apoptosis.
Dysregulated cytokine signaling is a hallmark of autoimmune diseases, chronic inflammation, cancer progression, and severe infectious responses such as cytokine storm syndromes.
Cytokine signaling pathway activity can be efficiently assessed by measuring gene expression of receptors, downstream regulators, and pathway-specific biomarker signatures.
Cytokine biomarker list
View the genes included in our cytokine-related qPCR arrays.
Promote immune activation and inflammation during infection or tissue damage.
Examples: IL-1, IL-6, TNF-α.
Limit excessive immune responses and maintain homeostasis.
Examples: IL-10, TGF-β.
Mediate communication between leukocytes and regulate immune differentiation.
Control immune cell trafficking and migration to inflammatory sites.
Induce antiviral states and modulate innate and adaptive immunity.
Cytokines activate several core signaling cascades:
Crosstalk between these pathways creates complex regulatory networks that fine-tune immune responses.
Autoimmune and inflammatory diseases
Persistent overproduction of pro-inflammatory cytokines drives conditions such as rheumatoid arthritis, psoriasis, inflammatory bowel disease and lupus.
Cytokine storm syndromes
Excessive cytokine release during severe infections (e.g., sepsis or viral infections) can lead to systemic inflammation and organ failure.
Cancer
Cytokines shape the tumor microenvironment, influence immune evasion, and regulate tumor growth and metastasis.
Chronic metabolic and neuroinflammatory disorders
Altered cytokine signaling contributes to obesity, insulin resistance, neurodegeneration and cardiovascular disease.
Cytokines are both therapeutic targets and therapeutic agents:
Accurate cytokine biomarker profiling is essential for monitoring disease progression and predicting therapeutic response.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to cytokine pathway analysis.
Our solutions enable researchers to:
What can be analyzed?
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
Cytokine signaling pathways are molecular communication networks activated when cytokines bind to their receptors. These pathways regulate immune responses, inflammation, cell survival, and differentiation through cascades such as JAK-STAT, NF-κB, MAPK, and PI3K-AKT.
Cytokines control both pro-inflammatory and anti-inflammatory responses. Pro-inflammatory cytokines like IL-1, IL-6, and TNF-α promote immune activation, while anti-inflammatory cytokines such as IL-10 help resolve inflammation and maintain tissue homeostasis.
Dysregulated cytokine signaling contributes to autoimmune diseases, chronic inflammation, cancer progression, cytokine storm syndromes, and metabolic disorders. Both excessive and insufficient cytokine activity can disrupt immune balance.
A cytokine storm is an excessive and uncontrolled release of pro-inflammatory cytokines that can lead to systemic inflammation, organ damage, and life-threatening complications, often observed in severe infections or immune dysregulation.
Cytokine signaling activity can be analyzed by measuring gene expression of cytokines, receptors, and downstream pathway regulators using targeted gene expression tools such as qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Cytokines | CT1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Cytokines | CT1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Cytokines | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Cytokines | ******* |
Biomarker list in progress. |
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1. R.A.Prell, J.M.Tarrant. Cytokines: Role in Homeostasis and Disease States(2018) 428-466.
2. Lierova A et al. Cytokines and radiation-induced pulmonary injuries.Signal Transduct Target Ther. J Radiat Res. (2018) 31.
3. Monastero RN et Pentyala S. Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels. Int J Inflam. (2017).
4. Méndez-García LA et al. Breast Cancer Metastasis: Are Cytokines Important Players During Its Development and Progression? J Interferon Cytokine Res. (2018) 13.
5. Setrerrahmane S, Xu H. Tumor-related interleukins: old validated targets for new anti-cancer drug development.Mol Cancer. (2017) 19;16(1):153.
6. Kothur K et al. CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review.Cytokine. (2016);77:227-37.