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The mTOR signaling pathway (mechanistic Target of Rapamycin) is a master regulator of cell growth, metabolism, survival, and stress adaptation. It integrates signals from nutrients, growth factors, energy status, and cellular stress to maintain homeostasis and enable cells to adapt to changing environmental conditions.
mTOR functions as a central signaling hub controlling anabolic and catabolic processes, including protein synthesis, lipid metabolism, autophagy, and immune cell activation. Dysregulation of mTOR signaling is implicated in cancer, metabolic disorders, neurodegeneration, and immune dysfunction.
mTOR pathway activity can be efficiently assessed by measuring gene expression of core regulators, downstream targets, and pathway-specific biomarker signatures.
mTOR signaling pathway biomarker list
View the genes included in our mTOR pathway qPCR arrays.
mTOR exists in two functionally distinct complexes with complementary roles.
Cross-regulation:
mTORC1 activity influences downstream signaling networks that indirectly affect mTORC2, highlighting strong pathway interconnectivity.
Accurate biomarker profiling is essential to guide therapeutic strategies and patient stratification.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to mTOR pathway analysis.
Our solutions allow researchers to:
What can be analyzed?
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
mTORC1 promotes protein synthesis and cell proliferation; mTORC2 enhances survival via AKT and cytoskeletal organization.
Key genes: MTOR, RPTOR, RICTOR, AKT1/2/3, AMPK, TSC1/2, S6K1, 4E-BP1.
PI3K/AKT activates mTORC1/2, linking nutrient and growth factor signals to cell growth and survival.
Dysregulation leads to uncontrolled growth, metabolic imbalance, and therapy resistance.
The mTOR pathway is activated by nutrients, growth factors, and cellular energy status. PI3K/AKT signaling, amino acids, and insulin stimulate mTORC1, while growth factors primarily regulate mTORC2.
mTOR regulates cell growth, proliferation, metabolism, survival, and autophagy, ensuring adaptation to environmental changes and maintaining cellular homeostasis.
mTORC1 promotes protein synthesis by phosphorylating key targets such as S6 kinase (S6K1) and 4E-BP1, increasing ribosome activity and translation efficiency.
mTORC1 mainly controls protein synthesis, metabolism, and autophagy in response to nutrients and energy levels, while mTORC2 regulates cell survival, cytoskeletal organization, and AKT activation in response to growth factors.
You can review the biomarker list for the mTOR pathway in the table below to see if it matches your research focus. If the targets you need are not included, you can customize your own SignArrays® by downloading and completing our Personalized SignArrays® information file. Send it to [email protected] to get started on your project.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
mTOR Signaling Pathway | MTOR1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
mTOR Signaling Pathway | MTOR1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
mTOR Signaling Pathway | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
mTOR Signaling Pathway | ******* |
Biomarker list in progress. |
Looking for more answers? Visit our Help & FAQ section to find detailed informations about our products, services, and technical support.
1. Saxton RA et Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. (2017)9;168(6):960-976.
2. Das A et al. mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging. Oxid Med Cell Longev. (2017).
3. Chamcheu JC et al. Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy. Cells. (2019)31;8(8).
4. Wei X et al. Roles of mTOR Signaling in Tissue Regeneration. Cells. (2019)12;8(9).
5. Kwasnicki A et al. Involvement of mTOR signaling pathways in regulating growth and dissemination of metastatic brain tumors via EMT. Anticancer Res. (2015);35(2):689-96.
6. Paquette M et al. mTOR Pathways in Cancer and Autophagy. Cancers (Basel). (2018);10(1).
7. Hua H e t al. Targeting mTOR for cancer therapy. J Hematol Oncol. (2019);12(1):71.