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Tumor microenvironment

The cell microenvironment (1)

The micro-cellular environment encompasses neighboring cells and their direct environment:

  • Fibroblasts.
  • Vascular cells.
  • Dendritic cells.
  • Immune system cells.
  • Some specific components according to the type of tissue (hormones, growth factors, etc.).
  • All these elements bathe in the ExtraCellular matrix (ECM).

The ECM is a major element of the cell’s microenvironment. In fact, the cell is able to anchor itself and move, by interacting with the ECM. The ECM itself in composed of many elements: (laminins, collagen, fibronectins, elastins, etc.) In physiological conditions, the microenvironment of the cell provides a tumor suppressor role.

The role of the tumor microenvironment in tumor progression can be studied by qPCR arrays specific of these signaling pathways (AnyGenes® SignArrays®).

Role of the tumor microenvironment in tumor progression and the clinical applications (Review) (2016)

The Tumor microenvironment (2)

Cancer cells can create for themselves an ideal environment, suited to their survival and proliferation. To do so, they can reprogram the metabolism of cells present in their environment (such as fibroblasts) and use it to their advantage, in order to induce growth and survival signals.

Moreover, the secretion of various factors (pro-angiogenic factors (VEGFA, PDGFA & PDGFB, FGF1 & FGF2…), pro-inflammatory factors (TNFA, IL8…) or anti-inflammatory factors (IL10, TGFB…)) and the interaction between tumor cells and surrounding cells can lead to the activation of several signaling pathways or mechanisms such as angiogenesis, adhesion-migration-invasion, cell proliferation, which will promote the colonization of new tissues through metastasis. (3) (4)

Those elements prove that the tumor microenvironment is deeply involved in tumor growth and proliferation.

AnyGenes® offers you the possibility to perform a high-throughput analysis of the tumor microenvironment to understand and identify the different signaling pathways involved, thanks to a single transcriptomic analysis.

To discover our associated products and reagents :

  1. ©Rôle du microenvironnement dans la tumorigenèse et la progression tumorale. Collection Rapports sur les avancées, ouvrage collectif édité par La Fondation ARC pour la recherche sur le cancer et l’INCa, Boulogne-Billancourt, avril 2013.
  2. Yuan Y, et al. (2016). Role of the tumor microenvironment in tumor progression and the clinical applications (Review). Oncol Rep, 35(5) :2499-515.
  3. Catalano V, et al. (2013) Tumor and its microenvironment: A synergistic interplay. Semin Cancer Biol, (6 Pt B) :522-32.
  4. Bolouri H, (2014). Network dynamics in the tumor microenvironment. Semin Cancer biol, 30 : 52-9.