In 2015, Iyer MK, et al. (3) classified nearly 58000 lncRNA whose role is little known. However, the same team demonstrates that lncRNAs are regulators of the physiology of certain tissues and that they are involved in many pathologies such as cancer, cardiovascular diseases or autoimmune diseases. Their numerous roles and their ubiquity in the human body make them very efficient biomarkers.
In 2016, Schmitt AM and Chang HY (4) identified 499 lncRNAs as playing a key role in cell growth. In addition, 89% of those who had a role for a given cell type had no functional role in another cell type.
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