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Signaling Pathways title  PI3K-Akt signaling pathway

PI3K/AKT is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, proliferation, migration, differentiation, angiogenesis, apoptosis, metabolism and protein synthesis (1,4).
PI3K-Akt-signaling-pathway

 
Upstream activation of the PI3K/Akt signaling pathway (2)
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Signaling Pathways title  PI3K-Akt signaling and diseases

The PI3K/Akt signaling pathway controls hallmarks of cancer, including cell survival, metastasis and metabolism (2), in adition to its important role in multidrug resistance in a variety of cancers, such as breast cancer, leukemia, lung cancer, ovarian cancer, hepatocellular carcinoma, and melanoma (3). PI3K/Akt signaling is implicated in numerous pathologies like skin diseases, autoimmune diseases, neurodegenerative diseases and brain tumor metastasis…(4,5).
(1) Jafari M et al. PI3k/AKT signaling pathway: Erythropoiesis and beyond. J Cell Physiol. (2019);234(3):2373-2385.
(2) He Y et al. Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduct Target Ther. (2021);6(1):425.
(3)Liu R et al. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis. (2020);11(9):797.
(4) Teng Y et al. The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells. (2021);10(5):1219.
(5) Chu E et al. Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation. J Neuroinflammation. (2021);18(1):276.
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