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mTOR pathway (mamalien or mechanistic target of rapamycin mTOR), an atypical serine/threonine kinase, through two distinct protein complexes mTORC1 and mTORC2, coordinates eukaryotic cell growth and metabolism with environmental inputs including nutrients and growth factors. Other external stresses, such as oxygen deprivation (hypoxia), radiation, high salt concentration, DNA topoisomerase inhibitors, and histone deacetylase inhibitors, also regulate this pathway (1,6).
The distinct roles of mechanistic target of rapamycin were identified in gene transcription, protein synthesis, tissue regeneration and repair, oxidative stress, immunity, aging, and cell death that include autophagy and apoptosis, insulin resistance, adipogenesis, and T-lymphocyte activation (2,4).You can check the biomarker list included in this pathway, see below: