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Signaling Pathways title  JAK-STAT signaling pathways

The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation (1).
JAK-STAT-Signaling-Pathway

 
The schematic structures of the JAK and STAT proteins and overview of the JAK/STAT pathway (4)
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Signaling Pathways title  JAK-STAT signaling pathways and diseases

Besides its important impact in cellular signaling, the JAK/STAT pathway has been associated with several diseases such as Rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, sepsis (1), inflammatory bowel disease (2), COVID-19 infection... (4).
Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development including myeloproliferative neoplasms (MPNs), cutaneous T-cell lymphoma (CTCL), lung cancer, gastric cancer, prostate cancer, colon cancer. cervical cancer, breast cance... (1,3,5).
(1) Xin P, et al. The role of JAK/STAT signaling pathway and its inhibitors in diseases. Int Immunopharmacol. (2020);80:106210.
(2) Cordes F, et al. Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease. World J Gastroenterol. (2020);26(28):4055-4075.
(3) Gutiérrez-Hoya A, & Soto-Cruz I. Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins. Cells. (2020);9(10):2297.
(4) Goker Bagca B, & Biray Avci C.The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19. Cytokine Growth Factor Rev. (2020);54:51-62.
(5) Shao F, et al. Targeting the JAK/STAT Signaling Pathway for Breast Cancer. Curr Med Chem. (2021);28(25):5137-5151.
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