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Biomarker and signaling pathways profiler.
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  • Signaling Pathways (SignArrays® System)

Signaling Pathways title   Real-time PCR arrays for your signaling pathways analysis


AnyGenes® helps you to analyse your favorite signaling pathways (SignArrays®) in less than 3 hours at very competitive prices.


Since more than 10 years, AnyGenes® team is proud to offer you a large panel of signaling pathways or gene expression assays that you can easily custom to your project needs.


Our SignArrays® are widely used by scientific community and are mentioned by high impact factor scientific publications, with positive feedbacks for the efficiency of our products. Indeed, AnyGenes® SignArrays® help in reducing time to get reliable qPCR array results, and accelerating publications rate.


AnyGenes® has developed and optimized the SignArrays® system with it range of Perfect Master Mix SYBR® Green to guarantee highly specific, reliable and reproducible qPCR arrays results, even with small amounts of precious samples like FFPE or LCM samples.

Select your SignArrays® among our large collection of signaling and pathological pathways:



Select your favorite Signaling Pathways (qPCR 96 or 384 plates) compatible with all qPCR instruments. SignPath Neuro AutoImmune Mental Cancer Other Pharmaco Personal

All our signaling pathways are validated at the experimental level on a large collection of tissues and cell lines on our high-throughput molecular platform, thanks to stringent and strong quality control criteria to guarantee you the best results.

We propose you a whole range of SignArrays® at the 96 or 384 plate format, compatible with most of all qPCR instruments on the market.

Each SignArray® 96 allows to analyse 84 genes of interest, specific to a signaling or pathological pathway with 8 reference genes necessary to the robust normalisation step of your qPCR data and 4 quality controls.


Available for many species : Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa and more on demand!


Example of Cytokines SignArray plate layout: 84 genes of interest, 8 house-keeping genes and 4 quality controls.
Example of Cytokines SignArray plate layout: 84 genes of interest, 8 house-keeping genes and 4 quality controls.
AnyGenes® monitors the reproducibility of their SignArrays with strict quality controls (example with 2 Human Apoptosis SignArrays performed from the same sample).
AnyGenes® monitors the reproducibility of their SignArrays with strict quality controls (example with 2 Human Apoptosis SignArrays performed from the same sample).

Signaling Pathways title   qPCR arrays SignArrays® characteristics:


  • ALL IN ONE SOLUTION
  •  STRICT INTRON SPANNING PRIMER DESIGN
  •  A FAST AND EASY PROTOCOL
  •  APPLICATIONS

Specific signaling pathway (96 or 384 qPCR well plates)

+ Sensitive and highly accurate qPCR reagents
(Perfect Master Mix SYBR® Green & EvaGreen)

+ Free data analysis software

+ Compatible with all qPCR instruments
All-in-one solution SignArrays system to explore your favorite Signaling Pathways (SignArrays + qPCR reagents + Free data analysis software).
All-in-one solution SignArrays system to explore your favorite Signaling Pathways (SignArrays + qPCR reagents + Free data analysis software).

A free data analysis software is available to help you to analyse your qPCR SignArrays results.
A free data analysis software is available to help you to analyse your qPCR SignArrays results.

- In order to guarantee sensitive, specific and accurate results, every primer set is designed with highly stringent criteria and validated at the experimental level on a large collection of tissues and cell lines on our high-throughput molecular platform thanks to strict experimental quality controls.

- We offer you very high quality primers.

- With a primer design on 2 exons to guarantee high specificity in qPCR and avoid any contaminating gDNA amplification.

Strict intron spanning primer design to guarantee the high specificity of our qPCR primers.
Strict intron spanning primer design to guarantee the high specificity of our qPCR primers.

Your signaling pathway SignArrays® results in less than 3 hours !

AnyGenes® has standardised its signaling pathways SignArrays® protocols to let you perform your qPCR analysis in the easiest way.

You just have to prepare your qPCR mixes with the Perfect Master Mix SYBR® Green and your cDNA samples, and dispense !
An optimised protocol to ensure you SignArrays Signaling Pathways results in less than 3 hours !
An optimised protocol to ensure you SignArrays Signaling Pathways results in less than 3 hours !

Your signaling pathways SignArrays® are perfect for many applications:


Gene expression profiling
Drug development
Biomarker signature identification
Validation of microarray results

Another application in mind according to your projects ? Please contact us at [email protected]
SignArrays Signaling Pathways can be used for many applications : from gene expression profiling to biomarker identification and validation.
SignArrays Signaling Pathways can be used for many applications : from gene expression profiling to biomarker identification and validation.

title Signaling pathways   Select your signaling pathways below :


Signaling Pathways

  • Adipogenesis

  • AMPK Signaling Pathway

  • Angiogenesis

    Angiogenesis, the formation of blood vessels, occurs in a coordinated series of steps, which can be divided into a destabilization, a proliferation, and a maturation phase.

    Extensive studies have revealed a variety factors involved in neoangiogenesis, the main protagonists are: Vascular endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), various members of the Transforming Growth factor beta (TGFβ) family and hypoxia (Hypoxia-inducible transcription factor, HIF)... Other factors that have angiogenic properties include the angiopoietins, (Ang-1); hepatocyte growth factor (HGF); Platelet-derived growth factor (PDGF-BB); Insulin-like growth factor family (IGF-1, IGF-2) and the Neurotrophins (NGF).

    One of earliest events in angiogenesis is the degradation of the vascular basement membrane and the remodeling of the extracellular matrix (ECM). Several matrix metalloproteinases (MMPs), including MMP-2, -3, and -9 play an important role in this system, and are associated with tumor progression, including invasion, metastasis, growth, migration, and angiogenesis.

    Integrins are the principle adhesion receptors used by endothelial cells to interact with the extracellular environment and are necessary for cell migration, proliferation, and survival.

  • Anti-Apoptotic Factors

  • Antibacterial Response

  • Antifungal Response

  • Antiviral Response

  • Apoptosis

    Apoptosis or programmed cell death is a highly regulated process critical for normal development and tissue homeostasis. Aberrant regulation of apoptosis can lead to cancer. Apoptosis is induced from signals inside or outside the cell including radiation, viral infection, growth factors, and hormones. Apoptosis involves signature morphological changes induced by caspases, which are activated upon induction of apoptotic signalling and cleave downstream molecules to facilitate the apoptotic cascade. The induction of apoptosis can occur through two pathways: the intrinsic apoptotic pathway which involves signalling through the mitochondria and the extrinsic apoptotic pathway which is initiated through activation of cell surface death receptors. Apoptotic signalling through the intrinsic pathway primarily involves activation of the proapoptotic Bcl-2 family members Bax and Bak, which facilitate release of cytochome C from the mitochondria and subsequent caspase-9 cleavage or activation. The activated caspase-9 will finally cleave or activate the downstream effector caspases such as caspase-3 and -7, leading to apoptosis.This pathway is negatively regulated by several antiapoptotic Bcl-2 family members such as Bcl-2 and Bcl-XL. Apoptotic signalling through the extrinsic pathway is initiated by ligand binding to death receptors or by induction of trimerization of the receptors. The death receptors belong to the tumor necrosis factor (TNF) receptor superfamily, which includes Fas, TNFR1, DR3, DR4 (TRAIL-R1),DR5(TRAIL-R2),and DR6.

  • Autophagy

    Autophagy is a lysosomal catabolic process that leads to sequestration and degradation of intracellular material. It functions at basal level in every cell and contributes to maintain cellular homeostasis, clearance of damaged organelles and adaptation to environmental stresses.
    In contrast, if the autophagy activity is too high, it may promote Apoptosis.
    Autophagy is involved in preventing certain types of disease: however dysfunction of autophagy has been implicated in multiple human diseases including cancer, neurodegeneration, and pathogen infection.
    Analyses of molecular mechanism have provided huge advances toward understanding the molecular basis of autophagy. The signaling pathways that are involved in mammalian autophagy imply specific genes or proteins called Atg, in particular Atg5 which exhibits a dual function by modelling both autophagy and apoptosis like Bcl-2. It is also well known that mTOR (target of rapamycin) an evolutionarily-conserved protein kinase, plays a crucial role as a regulator of autophagy.

  • Cardiomyocytes Signaling Pathway

  • Caspase Activation

  • Cell Cycle

  • Cell Cycle & Cancer

  • Cell Motility

  • Cell Proliferation

  • Cell Surface Markers

  • Cellular Senescence

  • Chemokines & Receptors

  • Cytokines

  • Dendritic Cells

  • EGF-PDGF Signaling Pathway

  • Endothelial To Mesenchymal Transition

  • Epigenetic Regulation

  • Epithelial To Mesenchymal Transition

  • ERBB Signaling Pathway

  • ERK Signaling Pathway

  • Estrogen Receptor & Breast Cancer

  • Fibrosis

  • G1-S Regulators

  • Growth Factors

  • Hematopoietic Stem Cells

  • HIF-1 Signaling Pathway

  • HIPPO Signaling Pathway

  • Human Leukocyte Antigen

  • Hypoxia

  • IL6-STAT3 Signaling Pathway

  • Immune Checkpoints

  • Immune Tolerance

  • Inflammation

  • Inflammation & Autoimmunity

  • Innate & Adaptive Immune Response

  • Integrated Stress Response

  • Interferons & Immune System

  • JAK-STAT Signaling Pathway

  • JNK Signaling Pathway

  • Long Non Coding RNA

  • Lymphangiogenesis

  • MAP Kinase (MAPK) Signaling Pathway

  • mTOR Signaling Pathway

  • Necrosis

  • NFKB Signaling Pathway

  • Nitric Oxide Signaling Pathway

  • Notch Signaling Pathway

  • Oncogenes

  • Osteogenesis

  • Oxidative Stress

  • Oxidative Stress & Antioxidant Defense

  • PI3K-AKT Signaling Pathway

  • Pluripotent Embryonic Stem Cells

  • Proteases

  • Protein Kinases

  • Proteo-Glycosaminoglycans Biosynthesis Genes

  • RAS-MAPK Signaling Pathway

  • Reference Genes

  • Signal Transduction

  • Stress & Toxicity Signaling Pathway

  • Surface Antigens (CD)

  • T & B Lymphocyte Activation

  • T helper 17 (Th17) & Cytokines Signaling Pathway

  • T Helper Cells Signaling Pathway

  • TGFβ Signaling Pathway

  • TNF Signaling Pathway

  • Toll-Like Receptors

  • Toxicity & Developmental Growth Factors

  • Transcription Factors

  • Transplant Rejection

  • Tumor Microenvironment

  • Tumor Supressors

  • Wntβ-catenin Signaling Pathway

  • Wound Healing

Neurodegenerative Diseases Pathways

  • Alzheimer's Disease

  • Amyotrophic Lateral Sclerosis

  • Huntington's Disease

  • Lysosomal Storage Disorder

  • Parkinson's Disease

  • Prion Disease

Autoimmune Diseases Pathways

  • Ankylosing Spondylitis

  • Autism Spectrum Disorders

  • Behçet's Disease

  • Crohn's Disease

  • Juvenil Diabetes (Type 1 Diabetes)

  • Multiple Sclerosis

  • Myasthenia Gravis

  • Psoriasis

  • Rheumatoid Arthritis

  • Systemic Lupus Erythematosus

  • Thyroiditis

  • Vitiligo

Mental Disorders Pathways

  • Anxiety Disorder

  • Bipolar Disorder

  • Major Depressive Disorder

  • Schizophrenia Disorder

Cancer Diseases

  • Adenocarcinoma

  • Bladder Cancer

  • Brain Cancer

  • Breast Cancer

  • Cervical Cancer

  • Chronic Lymphocytic Leukemia

  • Colorectal Cancer

  • Endometrial Cancer

  • Head & Neck Cancer

  • Liver Cancer

  • Lung Cancer

  • Lymphoma Cancer

  • Melanoma Cancer

  • Myeloma Cancer

  • Ovarian Cancer

  • Pancreatic Cancer

  • Prostate Cancer

  • Renal Cancer

  • Stomach Cancer

  • Thyroid Cancer

Other Pathologies

Pharmacological Pathways

  • Drug & Toxin Response

  • Drug Hepatotoxicity

  • Drug Metabolism

  • Drug Nephrotoxicity

  • Drug Neurotoxicity

  • Drug Resistance

Personalized SignArrays

As AnyGenes® policy is to propose you complete solutions at the closest of your scientific issues, you can custom your own SignArrays® with the genes of interest of your choice, according to your project.

You just have to download and complete our Personalized SignArrays® information file and send it at [email protected]

Standard SignArrays® 96 system
prices

Reference type : XXXH1-Y2S
Standard
Number of
SignArrays® 96
Price/unit
1-4
200 €
5-8
162 €
9-12
144 €
13-24
128 €
25-30
110 €
>30
80 €

* Y: R, A, B or F plate type, according to the qPCR instrument

(see Compatibility file)

*2: according to the number of SignArray® ordered

Customizable SignArrays® 96 system
prices

Reference type : PZXH1-Y2S
Customizable
Number of
SignArrays® 96
Price/unit
1-4
240 €
5-8
194 €
9-12
158 €
13-24
128 €
25-30
110 €
>30
80 €

* Y: R, A, B or F plate type, according to the qPCR instrument

(see Compatibility file)

*2: according to the number of Custom SignArray® ordered

example: PZXH1-R12S for 12 Personalized SignArrays® 96 for Light Cycler® 480 instrument

NB: The minimum order for customizable plates are 4 for less than 32 different genes/plate or 6 for more than 32 different genes/plate.

PMS Reagents associated with SignArrays® 96 prices

Reference type : PMS1-Z2S
PMS Perfect Master Mix SYBR® Green SignArrays® 96*
Number of
SignArrays® 96
Price/unit
1-4
95 €
5-8
80 €
8-12
72 €
13-24
69 €
>24
64 €

* 10 μl of PMS/reaction for 20 μl final volume

* Z: W, R, LR or F PMS, according to the qPCR instrument (see Compatibility file)

* 2: according to the number of PMS ordered

example: PMS1-W12S for 12 SignArrays® 96 for Light Cycler® 480 instrument


Standard SignArrays® 384 system
prices

Reference type : XXXH2-Y2S
Standard
Number of
SignArrays® 384
Price/unit
1-4
357 €
5-12
286 €
13-24
232 €
>24
196 €

* Y: R, A, B or F plate type, according to the qPCR instrument (cf Compatibility file)

(see Compatibility file)

*2: according to the number of SignArrays® ordered

example: AN1H2-R12S for 12 SignArrays® 384 for Light Cycler® 480 instrument

Customizable SignArrays® 384 system
prices

Reference type : PZXH2-Y2S
Customizable
Number of
SignArrays® 384
Price/unit
1-4
429 €
5-12
343 €
13-24
255 €
>24
196 €

* Y: R, A, B or F plate type, according to the qPCR instrument (cf Compatibility file)

*2: according to the number of Custom SignArray® ordered

example: PZXH2-R12S for 12 Personalized SignArrays® 96 for Light Cycler® 480 instrument

NB: The minimum order for customizable plates are 2 for less than 64 different genes/plate or 6 for more than 64 different genes/plate.

PMS Reagents associated with SignArrays® 384 prices

Reference type : PMS2-Z2S
PMS (Perfect Master Mix SYBR® Green) SignArrays® 384*
Number of
SignArrays® 384
Price/unit
1-4
189 €
5-12
170 €
13-24
161 €
>24
155 €

* 10 μl of PMS/reaction for 10 μl final volume

* Z: W, R, LR or F PMS, according to the qPCR instrument (cf Compatibility file)

*2: according to the number of PMS ordered

example: PMS2-W12S for 12 SignArrays® 384 for Light Cycler® 480 instrument


** For more information on prices, please contact us at [email protected] , or contact your local distributor