The cell microenvironment (1)
A large majority of the genome, about 98%, is considered noncoding.
However, the ENCODE project states that 80% of the genome has a
function (1). LncRNAs (long non-coding RNAs) are RNAs that do not
encode proteins and are constituted with more than 200 nucleotides (2).
But then what are they used for?
LncRNAs have no function as messenger RNA to be translated into
protein, but they are involved in many cellular mechanisms. Here is a
lncRNAs in Cancer PhenotypesLong Noncoding RNAs in Cancer Pathways. Cancer Cell. 2016
In 2015, Iyer MK, et al. (3) classified nearly 58000 lncRNA whose role is little known.
However, the same team demonstrates that lncRNAs are regulators of the physiology of
certain tissues and that they are involved in many pathologies such as cancer, cardiovascular
diseases or autoimmune diseases. Their numerous roles and their ubiquity in the human body make
them very efficient biomarkers.
In 2016, Schmitt AM and Chang HY (4) identified 499 lncRNAs as playing a key role in cell growth. In addition, 89% of those who had a role for a given cell type had no functional role in another cell type.
AnyGenes® offers you the possibility to perform a high-throughput analysis of these lncRNAs.
To discover our associated products and reagents :